Saskia Hagenaars and David Hill, researchers from the University of Edinburgh (UK), have conducted the largest genetic analysis ever done on the subject of baldness.
The study of the genome of more than 52,000 men, with or without baldness allowed them to point to 287 groups of genes involved in hair structure and development. Among them: many genes straight from ... the mother!
A major breakthrough in the study of the origins of baldness
Until then, only a few genes had been identified for their role in alopecia . From now on, scientists can argue that maternal genetic inheritance strongly influences hair loss .
"We have identified hundreds of new genetic signals, many of them related to male pattern baldness, that come from the X chromosome that men inherit from their mothers," Saskia Hagenaars showed in the study's findings, published in the PLOS Journal. Genes that play a role in the structure of the hair but also in their development, and therefore their fall.
Recall that in men, the X chromosome is inherited from the mother and the Y chromosome, determining in the differentiation of the sexes comes from the father - the women, they have two X chromosomes.
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Towards new anti-fall treatments?
"The results of this study could help identify the people who are most at risk of losing their hair , and also the potential genetic targets for the intervention," the researchers explain.
This major discovery allowed them to create an algorithm to try to anticipate the risks for a man to become bald, taking into account the presence or absence of certain genetic markers. For the moment, you can not define individual diagnoses based on the results. But they still make it possible to classify men into subgroups that define their predisposition to the loss of their hair.
For now, some solutions are already available to his gentlemen: they can opt for mesotherapy, a microcomfort technique by injections of hyaluronic acid, vitamins and minerals, which allows to revive atrophied vascularization of the hair follicle and to bring him at the same time all the ingredients he needs.
Implants, or the cloning of hair are also other possible solutions, although more expensive.
